Van de Ven Double Ends Everton's Run at Brand New Home Ground
The Dutch defender became the first backline player to score twice in a English top-flight match for Spurs since the Belgian defender in spring 2013.
Match summary
The Spurs defender nods into the net two times in first half
The home side's defender has equalizer ruled after video check
Senegalese midfielder nets third in dying moments
This loss is the Merseyside club's first at their new ground
Micky van de Ven found the net twice as Tottenham extended their unbeaten run on the road in the top division and handed the Toffees their first defeat at their new home.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the end of the previous campaign.
But Spurs captain the Dutchman struck twice from corners in the opening 45 minutes to put their impressive record at risk, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - nodded in a final goal to put the game to bed.
Jake O'Brien thought he had levelled the scores a short while after Van de Ven's opener, directing a bullet header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, missed a number of chances, while Vicario made a series of excellent saves to ensure Tottenham went five away games without defeat in the Premier League.
But the video assistant referee intervened, instructing Craig Pawson to check the score on the pitchside monitor and the referee ruled that the winger and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates Thomas Frank's side up to third in the division, five points off local foes and leaders Arsenal.
Everton remain in 14th position and are half a dozen points ahead of the drop zone.
Tottenham analysis: The defender excels in role at both ends of pitch
Following a drab midweek performance in the European competition against the French side, where they managed a only two shots on goal, the manager chose Randal Kolo Muani up front instead of ex-Everton forward Richarlison.
The new arrival was unable to make much of an impact before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the final outcome.
Defender Van de Ven transformed into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder heading the ball back across the six-yard box for an unmarked Van de Ven to score.
And the captain - filling in as skipper in Cristian Romero's unavailability - added his next goal in first-half stoppage time as he outjumped the England keeper to head home.
The Dutchman was equally impressive in defensive duties, partnering well with Kevin Danso as the duo dealt superbly with the 34 crosses sent their way by the opposition.
Toffees breakdown: Toffees lacking finishing touch
Everton's new home had been a happy hunting ground, but it seems the novelty may have faded somewhat and supporters flocked to the exits after the midfielder's final goal for Spurs.
The end in Everton's unbeaten home run will not be a major concern for the manager, but their striker situation are.
The forward and Thierno Barry - the Everton's two recognised centre-forwards - had scored only one league goal combined before the weekend's outing.
And they were failed to add to that poor record on a wet and gloomy night on Merseyside.
The striker's form was epitomized when he chose to overhead kick a clear chance from near the goal, despite having space and opportunity to reposition for a simpler attempt that would have challenged Vicario.
The substitute, too, failed to make an impact after replacing Beto in the second half.
It wasn't for a shortage of chance. The majority of the home side's offensive moves came through Grealish and Ndiaye, who relentlessly whipped threatening crosses into the Spurs penalty area.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men travel to the Stadium of Light in the top flight on early November at 20:00 GMT.
Spurs: The London club go to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup tie against the Magpies.